Abstract: As organizations struggle to become and remain competitive, the engagement of employees may be a critical enabler in achieving organizational goals, enhancing organizational competitiveness, and improving employee well-being. To this end, scholars have identified a continuing need for research focused on organizational factors within the purview of managers to improve the engagement of employees (Alagaraja & Shuck, 2015; Coyle-Shapiro & Shore, 2007; Eldor & Vigoda-Gadot, 2017; Oswick, 2015; Whittington et al., 2017; Whittington & Galpin, 2010). Using the employee engagement framework proposed by Shuck and Reio (2011), this research examined the relation among employee alignment, perceived organizational support, and employee engagement in an organizational context. The research site was the human resources department of a not-for-profit health care organization located in the southern region of the United States. Census sampling was used to identify the actual sample (Fritz & Morgan, 2010) of 109 full-time nonsupervisory employees whose data was used in the analysis. Three self-report survey instruments were used: (a) the Employee Engagement Scale (Shuck, Adelson, et al., 2017), (b) the Stringer Strategic Alignment Scale (Stringer, 2007), and (c) the Survey of Perceived Organizational Support (Eisenberger et al., 1986). Bivariate correlation and multiple regression analyses were used to test the research hypotheses. The results provided evidence of partial support for the researcher’s hypotheses, with four of the seven hypotheses supported. Evidence was found for a positive relation among employee alignment, perceived organizational support, and employee engagement, as well as the statistically significant contribution of employee alignment in explaining unique variance in employee engagement (i.e., 23.4%). Contrary to expectations, the results did not provide evidence that perceived organizational support had a statistically significant direct effect on employee engagement. Additionally, the results did not provide statistically significant evidence of either a moderation or mediation effect of perceived organizational support on the relation between employee alignment and employee engagement. This study provides preliminary evidence that suggests that employee alignment, and to a lesser extent perceived organizational support, are two factors within the purview of managers that can be useful in creating the requisite organizational environment in which engagement may thrive.